Lactoperoxidase is an integral part of the mammal natural defence system. It is a peroxidase enzyme secreted from mammary, salivary and other mucosal glands functions as a natural antibacterial enzyme. Lactoperoxidase is a member of the heme peroxidase enzymes and is encoded by the LPO gene in humans. It catalyzes the oxidation of several organic and inorganic substrate by hydrogen peroxide. These oxidised products produced through these reactions have potent bactericidal activities. It has a vital role in the innate immune system as it kills bacteria in milk and mucosal secretions hence may have therapeutic applications.